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      2. A 30 YEAR JOURNEY
        WITH A RELENTLESS
        FOCUS ON SCIENCE

        OUR HISTORY

        1988

        Leonard S. Schleifer, MD, PhD: Founder of Regeneron

        Regeneron is founded by Leonard S. Schleifer, MD, PhD, young neurologist and assistant professor at Cornell University Medical College

        1989

        George D. Yancopoulos, MD, PhD a molecular immunologist lauched Regeneron in 1989.

        George D. Yancopoulos, MD, PhD, a highly regarded young molecular immunologist at Columbia University, launches Regeneron

        1990

        Science publishes our first paper in 1990, which becomes the most highly cited neurobiology paper of the year.

        Science publishes our first paper, which becomes the most highly cited neurobiology paper of the year

        We announce a collaboration to develop neurotrophic factors

        1991

        REGN stock begins trading publicly on the NASDAQ in 1991

        REGN stock begins trading publicly on the NASDAQ; the Initial Public Offering raises $91.6 million

        1992

        Clinical development of Regeneron's first investigational drug began in 1992.

        Clinical development of our first investigational drug, a neurotrophic factor, begins

        1993

        Regeneron acquired space for a drug manufacturing facility in 1993.

        We acquire space for a drug manufacturing facility in Rensselaer, NY, years before having an FDA-approved product

        1995

        P. Roy Vagelos, MD becomes Chairman of the Board in 1995.

        Industry legend P. Roy Vagelos, MD, becomes Chairman of the Board, a position he still holds today

        Dr. Vagelos, another businessman-scientist who had previously led Merck's R&D division, encourages us to focus our research on disease settings where the biological profile can be fully characterized and the clinical benefit evaluated more quickly

        1997

        Phase 3 trial of first neurotrophic factor does not achieve primary endpoint in 1997.

        The Phase 3 trial of our first neurotrophic factor does not achieve its primary endpoint, and though the team is disappointed, we regroup to focus on new therapeutic solutions

        1999

        George Yancopoulos, MD, PhD becomes 11th most highly cited scientists in 1999.

        George Yancopoulos, MD, PhD, becomes the decade's 11th most highly cited scientist in the world

        2000

        ARCALYST injection begins clinical exploration in 2000.

        ARCALYST? (rilonacept) Injection, our first Trap technology, begins clinical exploration

        2003

        First paper on VelociGene? is published in 2003.

        Our first paper on VelociGene? is published, introducing the world to our proprietary Veloci technologies

        We become one of the original sponsors of the Westchester Science & Engineering Fair (WESEF) to support and reward scientific excellence in promising high school students

        2004

        EYLEA injection begins clinical development in 2004.

        EYLEA? (aflibercept) Injection begins clinical development

        2006

        Regeneron's first fully human antibody enters clinical development in 2006.

        A collaboration with Bayer HealthCare focuses on developing EYLEA? (aflibercept) Injection outside the U.S.

        Sarilumab, our first fully human antibody, enters clinical development

        2007

        Collaboration with Sanofi using VelocImmune? technology platform in 2007

        A collaboration with Sanofi focuses on developing fully human antibodies using our VelocImmune? technology platform

        2008

        FDA approval of ARCALYST injection in 2008

        The FDA approves our first medicine, ARCALYST? (rilonacept) Injection

        2009

        Regeneron hires its 1000th employee in 2009.

        We expand and extend our antibody collaboration with Sanofi

        PRALUENT? (alirocumab) Injection begins clinical development

        We hire our 1,000th employee and move into new buildings on our Tarrytown campus

        2010

        Regeneron begins to sponsor BioBus in 2010.

        We begin sponsorship of the BioBus, a mobile laboratory, to drive hands-on science education in underserved school districts

        2011

        EYLEA Injection is FDA approved in 2011.

        The FDA approves EYLEA? (aflibercept) Injection for its first indication

        Our President and CEO, Leonard S. Schleifer, is named Ernst & Young's 2011 New York Entrepreneur Of The Year?

        2012

        Named biotech company of the year in 2012

        The Science Top Employer survey names us the #1 employer in the global biopharmaceutical industry

        Scrip Intelligence names us Biotech Company of the Year

        2013

        Regeneron office opens in Dublin, Ireland in 2013.

        We announce the first recipients of our annual Regeneron Prize for Creative Innovation

        Our European business office opens in Dublin, Ireland

        Scrip Intelligence names Len and George as the "Management Team of the Year"

        2014

        Regeneron Genetics Center launches in 2014.

        The Regeneron Genetics Center, a new human genetics initiative, officially launches

        The FDA grants investigational antibody dupilumab Breakthrough Therapy designation

        We initiate the STEM Teaching Fellowship, a joint effort with the STEM Leadership Center, to develop a highly trained science teacher community, and Sci2Med Academy in collaboration with Yonkers Partners in Education to broaden career horizons for students who are underrepresented in the science fields

        We begin building our first ex-U.S. IOPS site in Limerick, Ireland

        2015

        PRALUENT Injection received FDA approval in 2015.

        The FDA approves PRALUENT? (alirocumab) Injection, our fourth FDA-approved medicine and first FDA-approved fully human monoclonal antibody

        We launch a major new immuno-oncology collaboration with Sanofi

        We enter into an agreement with the U.S. government for the development of a new antibody treatment for the Ebola virus

        2016

        Regeneron becomes new title sponsor for the Science Talent Search in 2016.

        We are named as the new title sponsor for the Science Talent Search (just the third in the prestigious competition's 75-year history)

        2017

        DUPIXENT Injection is FDA approved in 2017.

        KEVZARA Injection is FDA approved in 2017.

        The FDA approves DUPIXENT? (dupilumab) Injection, our fifth FDA-approved medicine

        FDA approves KEVZARA? (sarilumab) Injection, our sixth FDA-approved medicine and second fully human monoclonal antibody

        Recognized on the Civic 50 list of most community-minded companies in the United States

        2018

        Libtayo Injection receives FDA approval in 2018.Libtayo Injection receives FDA approval in 2018.DUPIXENT Injection is FDA approved for a new indication in 2018.

        2018 marks the thirtieth anniversary of Regeneron’s founding

        FDA approves Libtayo? (cemiplimab-rwlc) Injection, our seventh FDA-approved medicine

        The FDA approves a new indication for DUPIXENT? (dupilumab) Injection

        OUR HISTORY

        1988

        Leonard S. Schleifer, MD, PhD: Founder of Regeneron

        Regeneron is founded by Leonard S. Schleifer, MD, PhD, young neurologist and assistant professor at Cornell University Medical College

        1989

        George D. Yancopoulos, MD, PhD a molecular immunologist lauched Regeneron in 1989.

        George D. Yancopoulos, MD, PhD, a highly regarded young molecular immunologist at Columbia University, launches Regeneron

        1990

        Science publishes our first paper in 1990, which becomes the most highly cited neurobiology paper of the year.

        Science publishes our first paper, which becomes the most highly cited neurobiology paper of the year

        We announce collaboration to develop neurotrophic factors

        1991

        REGN stock begins trading publicly on the NASDAQ in 1991

        REGN stock begins trading publicly on the NASDAQ; the Initial Public Offering raises $91.6 million

        1992

        Clinical development of Regeneron's first investigational drug began in 1992.

        Clinical development of our first investigational drug, a neurotrophic factor, begins

        1993

        Regeneron acquired space for a drug manufacturing facility in 1993.

        We acquire space for a drug manufacturing facility in Rensselaer, NY, years before having an FDA-approved product

        1995

        P. Roy Vagelos, MD becomes Chairman of the Board in 1995.

        Industry legend P. Roy Vagelos, MD, becomes Chairman of the Board, a position he still holds today

        Dr. Vagelos, another businessman-scientist who had previously led Merck's R&D division, encourages us to focus our research on disease settings where the biological profile can be fully characterized and the clinical benefit evaluated more quickly

        1997

        Phase 3 trial of first neurotrophic factor does not achieve primary endpoint in 1997.

        The Phase 3 trial of our first neurotrophic factor does not achieve its primary endpoint, and though the team is disappointed, we regroup to focus on new therapeutic solutions

        1999

        George Yancopoulos, MD, PhD becomes 11th most highly cited scientists in 1999.

        George Yancopoulos, MD, PhD, becomes the decade's 11th most highly cited scientist in the world

        2000

        ARCALYST injection begins clinical exploration in 2000.

        ARCALYST? (rilonacept) Injection, our first Trap technology, begins clinical exploration

        2003

        First paper on VelociGene? is published in 2003.

        Our first paper on VelociGene? is published, introducing the world to our proprietary Veloci technologies

        We become one of the original sponsors of the Westchester Science & Engineering Fair (WESEF) to support and reward scientific excellence in promising high school students

        2004

        EYLEA injection begins clinical development in 2004.

        EYLEA? (aflibercept) Injection begins clinical development

        2006

        Regeneron's first fully human antibody enters clinical development in 2006.

        A collaboration with Bayer HealthCare focuses on developing EYLEA? (aflibercept) Injection outside the U.S.

        Sarilumab, our first fully human antibody, enters clinical development

        2007

        Collaboration with Sanofi using VelocImmune? technology platform in 2007

        A collaboration with Sanofi focuses on developing fully human antibodies using our VelocImmune? technology platform

        2008

        FDA approval of ARCALYST injection in 2008

        The FDA approves our first medicine, ARCALYST? (rilonacept) Injection

        2009

        Regeneron hires its 1000th employee in 2009.

        We expand and extend our antibody collaboration with Sanofi

        PRALUENT? (alirocumab) Injection begins clinical development

        We hire our 1,000th employee and move into new buildings on our Tarrytown campus

        2010

        Regeneron begins to sponsor BioBus in 2010.

        We begin sponsorship of the BioBus, a mobile laboratory, to drive hands-on science education in underserved school districts

        2011

        EYLEA Injection is FDA approved in 2011.

        The FDA approves EYLEA? (aflibercept) Injection for its first indication

        Our President and CEO, Leonard S. Schleifer, is named Ernst & Young's 2011 New York Entrepreneur Of The Year?

        2012

        Named biotech company of the year in 2012

        The Science Top Employer survey names us the #1 employer in the global biopharmaceutical industry

        Scrip Intelligence names us Biotech Company of the Year

        2013

        Regeneron office opens in Dublin, Ireland in 2013.

        We announce the first recipients of our annual Regeneron Prize for Creative Innovation

        Our European business office opens in Dublin, Ireland

        Scrip Intelligence names Len and George as the "Management Team of the Year"

        2014

        Regeneron Genetics Center launches in 2014.

        The Regeneron Genetics Center, a new human genetics initiative, officially launches

        The FDA grants investigational antibody dupilumab Breakthrough Therapy designation

        We initiate the STEM Teaching Fellowship, a joint effort with the STEM Leadership Center, to develop a highly trained science teacher community, and Sci2Med Academy in collaboration with Yonkers Partners in Education to broaden career horizons for students who are underrepresented in the science fields

        We begin building our first ex-U.S. IOPS site in Limerick, Ireland

        2015

        PRALUENT Injection received FDA approval in 2015.

        The FDA approves PRALUENT? (alirocumab) Injection, our fourth FDA-approved medicine and first FDA-approved fully human monoclonal antibody

        We launch a major new immuno-oncology collaboration with Sanofi

        We enter into an agreement with the U.S. government for the development of a new antibody treatment for the Ebola virus

        2016

        Regeneron becomes new title sponsor for the Science Talent Search in 2016.

        We are named as the new title sponsor for the Science Talent Search (just the third in the prestigious competition's 75-year history)

        2017

        DUPIXENT Injection is FDA approved in 2017.

        The FDA approves DUPIXENT? (dupilumab) Injection, our fifth FDA-approved medicine

        FDA approves KEVZARA? (sarilumab) Injection, our sixth FDA-approved medicine and second fully human monoclonal antibody

        Recognized on the Civic 50 list of most community-minded companies in the United States

        2018

        2018 marks the thirtieth anniversary of Regeneron’s founding

        FDA approves Libtayo? (cemiplimab-rwlc) , our seventh FDA-approved medicine

        The FDA approves a new indication for DUPIXENT? (dupilumab) Injection

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